Pyruvate Kinase Deficiency

Essential
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Synonyms

• Nonspherocytic Hemolytic Anemia, Hereditary with reduced PK Kinetics

Problem Communities

• None

General Conversation
Red cell pyruvate kinase deficiency is a genetic blood problem characterized by a deficiency of the enzyme pyruvate kinase. Physical searchings for related to the disorder could include minimized degrees of oxygen-carrying hemoglobulin in the blood due to untimely destruction of red cell (hemolytic anemia); uncommonly enhanced degrees of bilirubin in the blood (hyperbilirubinemia); uncommon augmentation of the spleen (splenomegaly); and/or various other problems. Pyruvate kinase shortage is inherited as an autosomal recessive hereditary characteristic. It is just one of a team of illness known as hereditary nonspherocytic hemolytic anemias. (Nonspherocytic refers to the fact that the red blood cells do not presume a spherical shape, as they finish with some blood problems.